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20:51 Jan 9, 2021 |
English to Russian translations [PRO] COVID-19 - Medical - Medical: Pharmaceuticals | |||||||
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| Selected response from: Igor Andreev Local time: 13:52 | ||||||
Grading comment
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Summary of answers provided | ||||
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4 +1 | открытая конформация |
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4 | внимание! |
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открытая конформация Explanation: Так понимаю, речь о характеристиках вакцины? антитела к вирусу с открытой конформацией S-белка см. Структура и конформационная изменчивость S-белка https://tinyurl.com/y2t93p6q To further structurally characterize the P2 spike protein, a cryo-electron microscopy (cryoEM) investigation of purified P2 S, expressed from DNA, was conducted. The cryoEM revealed, according to the Applicant, a particle population closely resembling the prefusion conformation of SARS-CoV-2 spike protein. By fitting a previously published atomic model on to a processed and refined cryoEM dataset, a rebuilt model was obtained showing good agreement with reported structures of prefusion full-length wild type S and its ectodomain with P2 mutations. In the prefusion state the RBD undergo hinge-like conformational movements and can either be in an “up” position (open for receptor binding) or in a “down” position (closed for receptor binding). Three-dimensional classification of the dataset showed a class of particles that was in the conformation one RBD ‘up’ and two RBD ‘down”. This partly open conformation represented 20.4% of the trimeric molecules. The remainder were in the all RBD ‘down’ conformation. Although potent neutralizing epitopes have been described when the RBD is in the “heads down” closed conformation, the “heads up” receptor accessible conformation exposes a potentially greater breadth of neutralizing antibody targets. It is concluded that antibodies to both the up and down conformations will potentially be formed upon immunisation with the P2 S encoding BNT162b2. https://www.ema.europa.eu/en/documents/assessment-report/com... К тому времени, когда антитела выработались в нужном для нейтрализации вируса титре к вирусу с открытой конформацией S-белка, вирус с закрытой конформацией S-белка может дать о себе знать. При этом он может составлять только малую часть вирусной нагрузки при начальном заражении. Однако нейтрализующие антитела к открытой конформации S-белка, достигнув высокой концентрации, начнут находить этот вирус с закрытой конформацией S-белка и образовывать с ним нестабильные комплексы. https://www.elibrary.ru/download/elibrary_43002901_50235726.... |
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внимание! Explanation: Ср. Thanks for the heads up on the credit card. Спасибо за предупреждение о кредитной карте. A simple heads up, that's all I needed. Простое предупреждение, это всё, что мне было нужно. (Reverso) -------------------------------------------------- Note added at 2 hrs (2021-01-09 23:04:56 GMT) -------------------------------------------------- Или сходное: «осторожно!» |
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