affinity maturation

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00:55 Oct 28, 2020
English to Swedish translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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Summary of translations provided
5affinitetsmognad
Lina Palm


  

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17 mins   confidence: Answerer confidence 5/5
affinitetsmognad


Definition from own experience or research:
Affinitetsmognad är en process som B-celler genomgår för att öka förmågan att binda till antigenen.

Example sentence(s):
  • Affinitetsmognad är ett immunsystemrespons. - Netinbag  
Lina Palm
Sweden
Local time: 22:06
Native speaker of: Native in SwedishSwedish
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