Glossary entry (derived from question below)
English term or phrase:
to (in contesto)
Italian translation:
to control gene ratio
Added to glossary by
liz askew
Feb 24, 2008 16:02
16 yrs ago
English term
Degree + PhD in Dentistry, ATA-Certified
Native in: Italian 
Works in: English to Italian, Italian to English, Italian
to (in contesto)
English to Italian
Medical
Genetics
Contesto:parametro di risposta molecolare alla terapia.
BCR-ABL to control gene ratio according to international scale
Avrei gentilmente bisogno di un parere di qualcuno esperto, con una certa urgenza.
Sbaglio io...oppure quel "to" è errato, fuori luogo, in più, e dovrebbe essere eliso?
Per me la frase corretta è:
BCR-ABL control gene ratio according to international scale
Grazie.
BCR-ABL to control gene ratio according to international scale
Avrei gentilmente bisogno di un parere di qualcuno esperto, con una certa urgenza.
Sbaglio io...oppure quel "to" è errato, fuori luogo, in più, e dovrebbe essere eliso?
Per me la frase corretta è:
BCR-ABL control gene ratio according to international scale
Grazie.
Proposed translations
(Italian)
| 4 | to control gene ratio |
liz askew
|
Change log
Feb 24, 2008 16:58: liz askew Created KOG entry
Proposed translations
12 mins
Selected
to control gene ratio
http://216.239.59.104/search?q=cache:OKi7zGszJGkJ:www.sussex...
Molecular response
Complete – transcript non quantifiable and non detectable.
Major – BCR/ABL to control gene ratio ≤0.10 according to the international
scale.
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Note added at 13 mins (2008-02-24 16:15:40 GMT)
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[PDF]
CHRONIC MYELOID LEUKAEMIA
File Format: PDF/Adobe Acrobat - View as HTML
Cytogenetic. response. Molecular response. (BCR-ABL to control. gene ratio according to. the international scale). Definitions. Complete: Platelet count < ...
www.gmccn.nhs.uk/hp/portal_repository/files/CML-GMCCN-final... - Similar pages
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Note added at 21 mins (2008-02-24 16:24:30 GMT)
--------------------------------------------------
You need to refer to a native English site, as I have done, to ensure the correct phraseology.
The ones I found without the "to" were not native English sites.
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Note added at 27 mins (2008-02-24 16:29:55 GMT)
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http://216.239.59.104/search?q=cache:uNP5Zi_uyAEJ:www.molecu...
disease progression for at least 5 years.1
MMR is defined as greater than or equal to a 3-log reduction in the ratio of BCR-ABL to control gene from a standardized median baseline value.2
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Note added at 31 mins (2008-02-24 16:33:47 GMT)
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ABL Kinase Inhibitor Therapy for CML: Baseline Assessments and ...
The amount of BCR-ABL transcript in the peripheral blood, measured as a ratio of BCR-ABL to a control gene, provides an estimate of the number of terminally ...
asheducationbook.hematologylibrary.org/cgi/content/full/2006/1/211 - Similar pages
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Note added at 34 mins (2008-02-24 16:36:52 GMT)
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Hi
This isn't my field but I thought that
BCR-ABL = fusion gene?
rather than control gene
--------------------------------------------------
Note added at 36 mins (2008-02-24 16:38:45 GMT)
--------------------------------------------------
Yes, cos look:
{beta}-Glucuronidase Is an Optimal Normalization Control Gene for ...
BCR-ABL was first normalized to each control gene, as indicated in the legend box .... van Dongen JJ: Differential stability of control gene and fusion gene ...
jmd.amjpathol.org/cgi/content/full/8/3/385 - Similar pages
Molecular response
Complete – transcript non quantifiable and non detectable.
Major – BCR/ABL to control gene ratio ≤0.10 according to the international
scale.
--------------------------------------------------
Note added at 13 mins (2008-02-24 16:15:40 GMT)
--------------------------------------------------
[PDF]
CHRONIC MYELOID LEUKAEMIA
File Format: PDF/Adobe Acrobat - View as HTML
Cytogenetic. response. Molecular response. (BCR-ABL to control. gene ratio according to. the international scale). Definitions. Complete: Platelet count < ...
www.gmccn.nhs.uk/hp/portal_repository/files/CML-GMCCN-final... - Similar pages
--------------------------------------------------
Note added at 21 mins (2008-02-24 16:24:30 GMT)
--------------------------------------------------
You need to refer to a native English site, as I have done, to ensure the correct phraseology.
The ones I found without the "to" were not native English sites.
--------------------------------------------------
Note added at 27 mins (2008-02-24 16:29:55 GMT)
--------------------------------------------------
http://216.239.59.104/search?q=cache:uNP5Zi_uyAEJ:www.molecu...
disease progression for at least 5 years.1
MMR is defined as greater than or equal to a 3-log reduction in the ratio of BCR-ABL to control gene from a standardized median baseline value.2
--------------------------------------------------
Note added at 31 mins (2008-02-24 16:33:47 GMT)
--------------------------------------------------
ABL Kinase Inhibitor Therapy for CML: Baseline Assessments and ...
The amount of BCR-ABL transcript in the peripheral blood, measured as a ratio of BCR-ABL to a control gene, provides an estimate of the number of terminally ...
asheducationbook.hematologylibrary.org/cgi/content/full/2006/1/211 - Similar pages
--------------------------------------------------
Note added at 34 mins (2008-02-24 16:36:52 GMT)
--------------------------------------------------
Hi
This isn't my field but I thought that
BCR-ABL = fusion gene?
rather than control gene
--------------------------------------------------
Note added at 36 mins (2008-02-24 16:38:45 GMT)
--------------------------------------------------
Yes, cos look:
{beta}-Glucuronidase Is an Optimal Normalization Control Gene for ...
BCR-ABL was first normalized to each control gene, as indicated in the legend box .... van Dongen JJ: Differential stability of control gene and fusion gene ...
jmd.amjpathol.org/cgi/content/full/8/3/385 - Similar pages
Note from asker:
| Ciao Liz, my doubt arise form the consideration that they ARE control genes...I hope I'm clear, so "to control" it doesn't make much sense to me. I also found other typos/mistakes in the text, and now I'm stuck on this one.. |
| The piece of chromosome 9 contains the gene c-ABL; the piece of chromosome 22 contains the gene BCR. Hence, the gene that is formed as a result is called the BCR-ABL gene. The new gene is responsible for producing a mutated protein which in turn converts the marrow stem cells from normal to leukemic. The resulting hybrid gene BCR-ABL codes for a fusion protein with tyrosine kinase activity, which activates signal transduction pathways, leading to uncontrolled cell growth http://www.bio.davidson.edu/courses/genomics/2001/oldham/CML.html |
| Thanks! Maybe "as a ratio of BCR-ABL to A control gene" as in your last reference, is the answer... |
| BCR-ABL viene chiamato gene di controllo, ovvero un gene che con la sua espressione controlla determinate reazioni. |
| Grazie MILLE! Mi hai davvero aiutato a chiarire il dubbio! http://www.ricercaitaliana.it/prin/unita_op_en-2005063732_004.htm |
4 KudoZ points awarded for this answer.
Comment: "Thanks a million!
Chiudo la domanda in anticipo, mi dispiacerebbe far perdere del tempo prezioso ad altri, visto che orami abbiamo chiarito. "
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