English to Spanish Medical Medical: Pharmaceuticals

Buenas tardes.

Estoy traduciendo sobre la farmacología de un medicamento, y esto dice en una diapositiva de PPT sobre el perfil farmacocinético de dabigatrán. Es para México.

Dabigatran:
High lipophilicity (no absorption)
Use of prodrug (dabigatran etexilate) increases bioavailability to 6.5%
Dose proportional increase: linear pharmacokinetics (10–1200 mg total daily dose)
Cmax (dose proportional)
AUC (dose proportional)
Dose–concentration response: dose proportional over wide range of doses
Single vs. multiple dosing: no time-depending changes in PK profile
Time to peak plasma concentration (Cmax=0.5–2h)
Plasma concentration-time profile: similar in young and older subjects
Plasma concentration: elderly females > elderly males > young subjects (because of decline in renal elimination)
Protein binding (only 30–35%)
Terminal half-life (independent of dose, t1/2= 14–17 hours)
Offset of action: Occurs in parallel with elimination
PK profile is predictable

Muchas gracias.

Lorena