Glossary entry (derived from question below)
English term or phrase:
KDEL receptor mediator pathway
Spanish translation:
ruta mediada del/por el receptor KDEL
English term
KDEL receptor mediator pathway
Entiendo que KDEL es un motivo, entonces para saber la correcta traducción del término.
Pseudomonas aeruginosa is increasingly recognized as an emerging opportunistic pathogen of
clinical relevance [236]. As with other species, it is ubiquitous in the environment and can easily adapt
to adverse conditions. The human infections range from acute infections like endocarditis, meningitis
and septicemia to chronic lung infections in cystic fibrosis patients. Most infections occur in
immunocompromised patients, like AIDS patients, burn victims or patients undergoing
chemotherapy [237]. P. aeruginosa presents several virulence factors, including the exotoxin A
(ExoA/PE). It belongs to the same family of mono-ADP-ribosyltransferases of V. cholerae cholix
toxin, which catalyses the ADP rybosilation of eukaryotic eEF-2 and consequently inhibits protein
synthesis [238]. PE is translated from an ORF with 2760 bp as a monocistronic message and is a
protein of 613 amino acids, resulting from a 638 amino acid precursor that includes a hydrophobic
leader peptide of 25 amino acids [237]. As described before for cholix toxin, PE presents three distinct
functional domains. The first, the N-terminal Ia domain (a.a. 1–252) is responsible for cell
recognition [239]. Afterwards, the toxin enters the cell and is internalized in early endosomes, where it
is cleaved by the protease furin, originating two fragments: a N-terminal with 28 kDa and a C-terminal
with 37 kDa [240]. This last one is the active fragment and is released in a pH dependent process.
Then it is transported to the endoplasmatic reticulum via late endosomes and Rab9-dependent route to
the trans-Golgi network and finally traveling by the KDEL receptor mediator pathway [241,242].
When the enzymatic subunit of PE becomes present in the cytosol, it promotes the ADP ribosylation of
the eEF-2. The ADP-ribosylation mechanism develops as previously described for cholix toxin,
inactivating eEF-2 and inhibiting protein synthesis. Consequently, it leads to cell death.
Gracias por su trabajo.
4 | vía mediada del/por el receptor KDEL | marideoba |
Proposed translations
vía mediada del/por el receptor KDEL
Todas estas proteínas poseen una secuencia de aminoácidos muy específica en el C-terminal. Dicha secuencia es KDEL (Lys-Asn-GluLeu). Esta secuencia posee un receptor específico, no solo en la membrana del RER sino también en las vesículas que se ori
pero también hay un flujo de reciclado en sentido contrario mediado por vesículas recubiertas con proteínas COPI que parten de las zonas laterales de las cisternas y se dirigen hacia otras cisternas más próximas al lado cis. Es un orgánulo en consta
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