English to Russian Medical Medical (general) ангиогенез

There are striking differences between vessels forming in physiological versus pathological conditions.
In normal angiogenesis, new vessels rapidly mature and develop in an orderly structure with regular branching at defined angles. Blood flows regularly in these vessels. Normal vessels are stabilized as long as they are needed.
By contrast, in pathological angiogenesis, growing vessels never mature completely. Vessels grow tortuously and are disorganized, dilated, and leaky. This creates high interstitial pressure that hampers blood flow. Due to persistence of pro-angiogenic factors, pathological vessels never fully stabilize.
This difference in stability may be exploited to specifically prune those vessels that grow in pathological conditions.