English to Russian Medical Medical: Pharmaceuticals Nonclinical Overview

In a 9-month monkey study increased mesangial matrix in the kidney cortex was observed at 6 mg/kg/day (Table 2.6.7.7L, Study 2003-0386).
This reversible finding had been observed at 12 mg/kg/day in a previous, investigative 8-week oral toxicity study in cynomolgus monkeys with sunitinib (Table 2.6.7.7J, Study 1225-174).
The particular mechanism of the lesion is uncertain but may be due to protein deposition within the mesangium.