English to Russian Science Medical: Pharmaceuticals

A “Retroaldol/aldol intramolecular mechanism” was proposed by McLaughlin et al. as the mechanism of epimerization for paclitaxel (Scheme 1).
In this proposed mechanism, the hydroxyl hydrogen is transferred from C7 to the C9 carbonyl with concomitant aldehyde formation at C7, ring cleavage between C7 and C8, doublebond formation between C8 and C9, and hence enol formation at C9 in a concerted mechanism.