Glossary entry (derived from question below)
English term or phrase:
target-mediated sink effect
Polish translation:
zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD)
Added to glossary by
Ewa Chojnowska
Mar 4, 2021 16:46
3 yrs ago
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English term
roaming those boundless translatitudes
Native in: Polish 
Works in: Polish to English, English to Polish, French to Polish, and 8 more.
target-mediated sink effect
English to Polish
Medical
Medical: Pharmaceuticals
MM
Figures show the agent serum concentrations over time. In most patients, a dominant target-mediated sink effect was observed leading to low or no detectable serum trough levels. In contrast, patients treated with a higher dose showed constant or slightly accumulating trough level.
Proposed translations
(Polish)
| 2 | zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD) |
Frank Szmulowicz, Ph. D.
|
Proposed translations
1 hr
Frank Szmulowicz, Ph. D.
United States
United States
Native in English
&
Polish
Works in field
United States
On time, on target, on budget.
Native in: English 
, Polish
Works in: Polish to English, English to Polish, Russian to Polish, and 1 more.
Related KudoZ points
:
360
Selected
zjawisko wysokiego powinnowactwa substancji do miejsc wiążących (ang. TMDD)
This should be the same as TMDD, that is, target-mediated drug disposition. I have not found a Polish term so I provided a descriptive definition.
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is known as target-mediated drug disposition (TMDD) or the "antigen sink effect" (Krippendorff et al., 2009;Mager, 2006;Wang et al., 2012).
https://www.researchgate.net/publication/7305753_Target-medi...
cccccccccccccccccccccccccccccccccccccccc
Target-mediated drug disposition (TMDD) is a term to describe a nonlinear pharmacokinetics (PK) phenomenon that is caused by high-affinity binding of a compound to its pharmacologic targets.
cccccccc
is known as target-mediated drug disposition (TMDD) or the "antigen sink effect" (Krippendorff et al., 2009;Mager, 2006;Wang et al., 2012).
https://www.researchgate.net/publication/7305753_Target-medi...
cccccccccccccccccccccccccccccccccccccccc
Target-mediated drug disposition (TMDD) is a term to describe a nonlinear pharmacokinetics (PK) phenomenon that is caused by high-affinity binding of a compound to its pharmacologic targets.
4 KudoZ points awarded for this answer.
Comment: "Bardzo dziękuję."
Discussion