Glossary entry (derived from question below)
English term or phrase:
on-rate, off-rate
Serbian translation:
brzina vezanja, brzina otpuštanja
Added to glossary by
Svetomir Mijovic
Sep 13, 2022 21:24
1 yr ago
11 viewers *
English term
Serbia
Experienced Sci/Tech translator
Native in: Serbian 
, Serbo-Croat (Variant: Serbian)
Works in: Serbo-Croat to English, English to Bosnian, English to Croatian, and 1 more.
on-rate, off-rate
English to Serbian
Medical
Medical: Pharmaceuticals
Antibody derivatives
The low affinity of CAT192 was characterized by a very slow on-rate but also a very slow off-rate. The slow on-rate and off-rate suggested that the binding between CAT192 and TGFβ1 may require a potential conformational change which was limited by unfavorable amino acids in CAT192(IgG4). Described here are experiments designed to increase flexibility/affinity of the Fab or IgG versions of the scFv by adding additional amino acids in the light chain elbow region, which links the antibody Fv domain to the CH1 domain.
Proposed translations
(Serbian)
| 3 | brzina vezanja, brzina otpuštanja |
Nebojša Mihaljević
|
| 4 | stopa asocijacije, stopa disocijacije |
Milan Nesic
|
Proposed translations
14 hrs
Nebojša Mihaljević
Montenegro
Montenegro
Native in Serbian
Montenegro
Translator & Electronic Engineer
Native in: Serbian (Variant: Montenegrin ) 
, Montenegrin
Works in: English to Serbian, English to Montenegrin, English to Serbo-Croat, and 6 more.
Related KudoZ points
:
52
Selected
brzina vezanja, brzina otpuštanja
Reference:
1. Binding interactions between selectins and their ligands have remarkably fast on and off rates (i.e. bond association and dissociation rates) that allow the initial capture of circulating leukocytes and their labile rolling interactions with the endothelium... (https://tel.archives-ouvertes.fr/tel-02280890/document)
2. Ponašanje kompleksa protein-ligand uvelike ovisi o njihovim termodinamičkim i kinetičkim svojstvima (odn. konstantama disocijacije i omjeru brzina vezanja i otpuštanja liganda („on/off”)) (https://hrcak.srce.hr/file/37330)
1. Binding interactions between selectins and their ligands have remarkably fast on and off rates (i.e. bond association and dissociation rates) that allow the initial capture of circulating leukocytes and their labile rolling interactions with the endothelium... (https://tel.archives-ouvertes.fr/tel-02280890/document)
2. Ponašanje kompleksa protein-ligand uvelike ovisi o njihovim termodinamičkim i kinetičkim svojstvima (odn. konstantama disocijacije i omjeru brzina vezanja i otpuštanja liganda („on/off”)) (https://hrcak.srce.hr/file/37330)
4 KudoZ points awarded for this answer.
Comment: "Hvala!"
17 hrs
stopa asocijacije, stopa disocijacije
"KD is the ratio of the antibody dissociation rate (koff), how quickly it dissociates from its antigen, to the antibody association rate (kon) of the antibody, how quickly it binds to its antigen."
https://www.abcam.com/primary-antibodies/kd-value-a-quantiti...
"Nagomilavanje analita s vremenom omogućava kvantificiranje stopa (kon), off offa (koff) konstanta disocijacije (Kd) i, u nekim aplikacijama, aktivnih koncentracija analita."
https://books.google.rs/books/publisher/content?id=yKT5DwAAQ...
https://www.abcam.com/primary-antibodies/kd-value-a-quantiti...
"Nagomilavanje analita s vremenom omogućava kvantificiranje stopa (kon), off offa (koff) konstanta disocijacije (Kd) i, u nekim aplikacijama, aktivnih koncentracija analita."
https://books.google.rs/books/publisher/content?id=yKT5DwAAQ...
Reference:
https://www.abcam.com/primary-antibodies/kd-value-a-quantitive-measurement-of-antibody-affinity
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