Glossary entry (derived from question below)
English term or phrase:
down-regulation, up-regulation
Serbian translation:
Негативна/позитивна регулација (гена)
Added to glossary by
Svetomir Mijovic
Aug 10, 2022 19:03
1 yr ago
13 viewers *
English term
down-regulation, up-regulation
English to Serbian
Medical
Medical: Pharmaceuticals
oligomer conjugates
To achieve a desired effect of specific gene down-regulation, the oligomers generally either promote the decay of the targeted mRNA, block translation of the mRNA or block the function of cis-acting RNA elements, thereby effectively preventing either de novo synthesis of the target protein or replication of the viral RNA.
However, such techniques are not useful where the object is to up-regulate production of the native protein or compensate for mutations that induce premature termination of translation, such as nonsense or frame-shifting mutations.
However, such techniques are not useful where the object is to up-regulate production of the native protein or compensate for mutations that induce premature termination of translation, such as nonsense or frame-shifting mutations.
Proposed translations
(Serbian)
3 | Негативна/позитивна регулација (гена) | Slobodan Kozarčić |
4 | nishodna regulacija, ushodna regulacija | Milan Nesic |
Proposed translations
21 mins
Selected
Негативна/позитивна регулација (гена)
https://en.wikipedia.org/wiki/Downregulation_and_upregulatio...
https://it.wikipedia.org/wiki/Sottoregolazione
https://hr.weblogographic.com/what-is-difference-between-pos...
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Note added at 4 days (2022-08-15 09:22:40 GMT) Post-grading
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Увек.
https://it.wikipedia.org/wiki/Sottoregolazione
https://hr.weblogographic.com/what-is-difference-between-pos...
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Note added at 4 days (2022-08-15 09:22:40 GMT) Post-grading
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Увек.
4 KudoZ points awarded for this answer.
Comment: "Hvala!"
1 day 7 hrs
nishodna regulacija, ushodna regulacija
"Conclusions: Complex pathological processes in CKD cause downregulation of AdipoR1 which could ultimately influence AdipoR1 protein levels leading to a state of »adiponectin resistance«."
"Zaključak: Kompleksni patološki procesi u HBI izazivaju nishodnu regulaciju AdipoR1 gena, što bi moglo uticati na nivo AdipoR1 proteina, vodeći u stanje »adiponektinske rezistencije«."
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"Ushodna regulacija ekspresije CD83 molekula
Upregulation of CD83 expression."
"Zaključak: Kompleksni patološki procesi u HBI izazivaju nishodnu regulaciju AdipoR1 gena, što bi moglo uticati na nivo AdipoR1 proteina, vodeći u stanje »adiponektinske rezistencije«."
________________________________
"Ushodna regulacija ekspresije CD83 molekula
Upregulation of CD83 expression."
Reference:
https://www.dmbj.org.rs/jmb/pdf/2016-4/8.pdf
http://www.doiserbia.nb.rs/img/doi/0025-8105/2012/0025-81051210388V.pdf
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