AAV packaging gene
Serbian translation: gen zadužen za pakovanje tj. sklapanje adenoviralne čestice
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| 11:45 Dec 13, 2022 |
| English to Serbian translations [PRO] Medical - Medical: Pharmaceuticals / fusion proteins | |||||||
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|  Selected response from: Nebojša Mihaljević Montenegro Local time: 08:08 | ||||||
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| 3 | gen zadužen za pakovanje tj. sklapanje adenoviralne čestice |
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| AAV = |
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Answers
23 days confidence: 
| aav packaging gene gen zadužen za pakovanje tj. sklapanje adenoviralne čestice Explanation: Reference: 1. https://rektorat.unios.hr/molekularna/dokumenti/storage/zavr... Na svojim krajevima DNA adenovirusa ima cis-djelujuće obrnuto ponavljajuće sljedove (engl. inverted terminal repeats, ITR) koji su potrebni za replikaciju adenoviralne DNA. U blizini lijevog ITR nalazi se cis-djelujući slijed za pakiranje (ψ) nužan za enkapsidaciju adenoviralne DNA. Ovisno o tome eksprimiraju li se prije ili nakon početka DNA replikacije, geni su podijeljeni na rane i kasne. U rane gene spada šest transkripcijskih jedinica: E1A, E1B, E2A, E2B, E3 i E4, čiji proteinski produkti omogućavaju replikaciju adenoviralne DNA. Kasni geni eksprimiraju se sa zajedničkog glavnog kasnog promotora (engl. major late promoter, MLP), čija premRNA podliježe alternativnom prekrajanju i diferencijalnoj poliadenilaciji rezultirajući s 5 kasnih transkripcijskih jedinica (L1, L2, L3, L4, L5). Kasni geni kodiraju za strukturne proteine adenovirusa kao i za proteine koji sudjeluju u sklapanju novih adenoviralnih čestica. 2. https://repository.fzsri.uniri.hr/islandora/object/fzsri:965... Proteini kasne regije zaduženi su za pravilno pakiranje virusnih čestica i omogućavanje izlaska virusne čestice. |
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Reference comments
33 mins |
| Reference: AAV = Reference information: Adeno-associated virus (AAV) Guide - Addgene https://www.addgene.org › guides › aav The short coding sequences of channelrhodopsins, halorhodopsins, and other optogenetic genes enables them to be packaged in AAVs. Click here for more ... -------------------------------------------------- Note added at 37 minutes (2022-12-13 12:22:53 GMT) -------------------------------------------------- I can only find this: mediated gene replacement therapy for neurological disorders https://eprints.whiterose.ac.uk › Circumventing th... by L Marrone · 2022 · Cited by 3 — While the ITRs allow the replication and ***packaging of the AAV genome***, rep encodes the four proteins required for replication (Rep40, Rep52, ... |
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