холостая активация
English translation: autoactivation
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| 06:59 Apr 21, 2023 |
| Russian to English translations [PRO] Art/Literary - Medical (general) / Hematology | |||||||
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|  Selected response from: Marlin31 Russian Federation Local time: 14:25 | ||||||
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| Summary of answers provided | ||||
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| 3 | tickover activation (mechanism) |
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| 3 | idle activation |
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| 2 | alternative pathway |
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Answers
1 hr confidence: 
tickover activation (mechanism) Explanation: C3 tickover activation (mechanism) https://cyberleninka.ru/article/n/osobennosti-etiologii-i-pa... СЗ-кнвертаза представлена комплексом C3bBbP, фиксированном на липополисахариде (ЛПС). При этом белок С3 постоянно самопроизвольно расщепляется на С3а и С3Ь - «холостая активация». В результате этого в плазме все время поддерживается невысокая концентрация С3Ь, который связывает ЛПС клеточной стенки. https://www.frontiersin.org/articles/10.3389/fimmu.2022.9842... Activation of the plasma complement system occurs via three main mechanisms—the lectin pathway, initiated by mannose-binding lectin; the classical pathway, initiated by the antibody; and the alternative pathway initiated by C3b binding. Additionally, autoactivation can occur via the so-called C3-tickover mechanism. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820029/ Although the classical and lectin pathways generally are activated upon recognition of exogenous materials, the alternative pathway (AP) is constitutively active at low levels in the normal host. >b>This often is referred to as the tickover mechanism and allows the system to stay primed for rapid and robust activation. https://books.google.ru/books?id=2AaJqNl1QIYC&printsec=front... p. 562 C3 AND FACTOR B The alternative complement activation pathway starts with the freely circulating inactive serum protein C3. A spontaneous low level of hydrolysis (called C3 tickover activation)... |
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3 hrs confidence:
idle activation Explanation: Указанный процесс, также известный как холостая активация, происходит за счет спонтанного расщепления тиоэфирной связи в C3 с образованием C3i или C3(H2O) The initiation of convertase AP C3 occurs during spontaneous hydrolysis of the complement component C3, which is abundant in the plasma fraction of blood. This process, also known as idle activation, occurs due to spontaneous cleavage of the thioether bond in C3 to form C3i or C3 (H 2 O) https://patents.google.com/patent/EA035025B1/en |
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3 days 11 hrs confidence:
alternative pathway Explanation: the alternative pathway of complement activation. https://www.sinobiological.com/research/complement-system/co... https://studfile.net/preview/1152674/page:4/ https://en.wikipedia.org/wiki/Alternative_complement_pathway |
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